Science Friday

Last month, scientists reported a historic first: they gave the first personalized gene-editing treatment to a baby who was born with a rare life-threatening genetic disorder. Before the treatment, his prognosis was grim. But after three doses, the baby’s health improved. So how does it work? What are the risks? And what could this breakthrough mean for the 30 million people in the US who have a rare genetic disease with no available treatments? To help get some answers, Host Flora Lichtman is joined by the physician-scientists who led this research: geneticist Dr. Kiran Musunuru and pediatrician Dr. Rebecca Ahrens-Nicklas. Guests: Dr. Rebecca Ahrens-Nicklas is an assistant professor of pediatrics and genetics at the Children's Hospital of Philadelphia and the University of Pennsylvania. Dr. Kiran Musunuru is a professor of translational research at the University of Pennsylvania. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Australia is known for its unusual animal life, from koalas to kangaroos. But once upon a time, the Australian landscape had even weirder fauna, like Palorchestes azael, a marsupial with immense claws and a small trunk. There was Protemnodon mamkurra, a massive, slow-moving, kangaroo-like creature. And Zygomaturus trilobus, a wombat the size of a hippo. They’re all extinct now, and researchers are trying to figure out why. Host Flora Lichtman talks with researcher Carli Peters about ZooMS, a technique that allows researchers to use collagen from ancient bone fragments to identify species, offering clues to those ancient extinction events. Peters recently described using the technique in the journal Frontiers in Mammal Science. And, a recent study in the journal Nature Astronomy hints that our own Milky Way galaxy may not be doomed to collide with Andromeda after all. Till Sawala, an astrophysicist at the University of Helsinki, joins Flora to talk about the finding. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

As a grad student, Suchitra Sebastian wasn’t sure she wanted to be a physicist. But when one of her experiments gave an unexpected result, she was hooked. Suchitra’s former PhD student Beng Sing Tan describes the late-night experiments that led to an “impossible” finding—a potentially new state of matter. Theoretical physicist Piers Coleman tells us about working on the edges of a scientific field, and what happens when a new theory ruffles old feathers. “The Leap” is a 10-episode audio series that profiles scientists willing to take big risks to push the boundaries of discovery. It premieres on Science Friday’s podcast feed every Monday until July 21. “The Leap” is a production of the Hypothesis Fund, brought to you in partnership with Science Friday. Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

The James Webb Space Telescope (JWST) started collecting data nearly three years ago, and it has already transformed our understanding of the universe. It has spotted the earliest galaxies ever seen, and, closer to home, captured auroras around Jupiter. So what’s the latest from the JWST? In this live broadcast, Hosts Flora Lichtman and Ira Flatow talk with astrophysicist Macarena Garcia Marin, deputy project director for the James Webb Space Telescope. Guest: Dr. Macarena Garcia Marin is an astrophysicist and instrument scientist for the European Space Agency. She’s also deputy project director for the James Webb Space Telescope. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Ever noticed how some people get to their 80s and 90s and continue to be healthy and active? They spend their days playing mahjong, driving to lunch, learning shuffle dancing, and practicing Portuguese. Those are “super agers,” seniors who stay fit well into old age. How do they do it? Is it luck or genetics? In this live broadcast, Hosts Flora Lichtman and Ira Flatow discuss the science of aging with two experts on the topic, cardiologist Eric Topol and neuroscientist Emily Rogalski. Guests: Dr. Eric Topol is an author, practicing cardiologist at the Scripps Clinic, and a genomics professor at the Scripps Research Institute in La Jolla, California. Dr. Emily Rogalski is a clinical and cognitive neuroscientist, and the director of the Healthy Aging & Alzheimer’s Research Care Center at the University of Chicago. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

While there are a lot of dinosaur fossils, and a lot of plant fossils, the precise connection between the two has been something of a mystery. Now, researchers report that they’ve found what’s called a cololite, fossilized gut contents, in the remains of a sauropod—a massive, long-necked plant-eater. The dino’s last meal dates back 95 to 100 million years. Paleontologist Stephen Poropat joins Host Flora Lichtman to dig into the mysteries of a dinosaur’s tummy. And, for prairie dogs, communication is key. The rodents’ yips and barks can warn when danger is near—and not just to other prairie dogs. A new study suggests that birds called long-billed curlews are eavesdropping on this chatter to learn when a predator is lurking nearby. Using speakers and a taxidermied badger on wheels, ornithologists are untangling the social dynamics of black-tailed prairie dogs. Host Flora Lichtman talks with study author Andrew Dreelin about this eavesdropping behavior and what it means for conservation. Guests: Dr. Stephen Poropat is a paleontologist and deputy director of the Western Australian Organic and Isotope Geochemistry Centre at Curtin University in Perth, Australia. Andrew Dreelin is a research fellow with the Smithsonian Conservation Biology Institute and a PhD candidate at Northern Illinois University. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Last month, former President Joe Biden announced that he had been diagnosed with an aggressive form of prostate cancer. The news sparked a larger conversation about what exactly the best practices are to screen for prostate cancer. Turns out, it’s more complicated than it might seem. Host Ira Flatow is joined by oncologist Matthew Cooperberg and statistician Andrew Vickers, who studies prostate cancer screening, to help unpack those complexities. Guests: Dr. Matthew Cooperberg is a urologic oncologist and professor at the University of California, San Francisco. Dr. Andrew Vickers is a statistician who studies the efficacy of prostate cancer screening at Memorial Sloan Kettering Cancer Center based in New York City. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Biochemist Virginia Man-Yee Lee has spent a lifetime in the lab, figuring out what happens in the brains of people with neurodegenerative diseases. She’s made key discoveries about Parkinson's, ALS, and Alzheimer's.The secret to her success? Happiness. “If you're not happy, you don’t know what you’re capable of,” Lee says. Neurologist Ken Kosick reflects on the early days of Alzheimer’s research, and neurologist Alice S. Chen-Plotkin, a former postdoc in Virginia’s lab, gives us a fly-on-the-wall look at the unusual research partnership between Lee and her husband John Trojanowski. “The Leap” is a 10-episode audio series that profiles scientists willing to take big risks to push the boundaries of discovery. It premieres on Science Friday’s podcast feed every Monday until July 21. “The Leap” is a production of the Hypothesis Fund, brought to you in partnership with Science Friday. Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

On Monday, US Health Secretary Robert F. Kennedy Jr. fired all 17 members of the panel that advises the CDC on who should get certain vaccines and when. Then on Thursday, he appointed eight new members, some of whom have been critical of vaccines in the past. So who exactly is new on the panel and how are medical experts reacting? Sophie Bushwick from New Scientist breaks down this reshuffling and the other top science stories of the week, including Starlink’s leaky satellites, Earth’s possible past encounters with dark matter, IBM’s quantum computing plans, a device that can extract water from dry air, and how a paralyzed man was able to speak thanks to brain-controlled synthetic voice. Plus, nearly one in four Americans live within three miles of a Superfund site, places that are contaminated with hazardous waste and flagged for cleanup by the government. Amid sweeping cuts to science and environmental programs, the Trump administration appears to be prioritizing the cleanup of these polluted sites. But why? Host Flora Lichtman talks with science journalist Shahla Farzan about the Trump administration’s approach to cleaning up Superfund sites and what this means for impacted communities. Read Farzan’s full story about the move to expedite cleanup, and her past coverage of how floods can impact the areas surrounding Superfund sites. Transcripts for each episode are available within 1-3 days at sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

This week, China’s Tianwen-2 spacecraft sent back its first image from space. It’s headed to a rendezvous with the asteroid Kamoʻoalewa, one of Earth’s “quasi-moons,” where it will collect samples in 2026. The mission comes after several successful lunar missions, including a lunar rover and a sample return mission from the far side of the moon. Host Ira Flatow talks with reporter Ling Xin from the South China Morning Post about the goals of China’s space program, and what might be ahead. Plus, astronomer Dean Regas describes his new “tactile astronomy” book, which seeks to bring stories of the constellations to young blind and low-vision readers. Guests: Ling Xin is a science reporter at the South China Morning Post based in Ohio. Dean Regas is an astronomer, host of the “Looking Up” podcast, and author of the new book All About Orion. Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

The prairie might just be the most underappreciated landscape in the United States. Beginning in the early 1800s, the majority of these grasslands were converted into big industrial farms. Now, some unaffectionately refer to it as “flyover country.” Host Ira Flatow talks with Dave Hage and Josephine Marcotty, authors of Sea of Grass: The Conquest, Ruin and Redemption of Nature on the American Prairie, about the loss of biodiversity on the American prairie and those working to restore what remains. Guests: Dave Hage is a longtime environmental reporter and co-author of Sea of Grass: The Conquest, Ruin and Redemption of Nature on the American Prairie, based in St. Paul, Minnesota. Josephine Marcotty is a longtime environmental reporter and co-author of Sea of Grass: The Conquest, Ruin and Redemption of Nature on the American Prairie, based in Minneapolis, Minnesota. Transcript will be available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Bedbug infestations are not just a modern problem—these pests have been with early human ancestors for 245,000 years, causing problems long before the invention of beds. Lindsay Miles, an entomologist at Virginia Tech, has found that changes in bedbug population size mirrored those of humans, proving they might be our first pest. Miles talks with Host Flora Lichtman about our history with bedbugs and why they’re such prolific pests. Plus, the discovery of a new wasp that catches its prey… with butt flaps. Dr. Lars Vilhelmsen, curator at the Natural History Museum of Denmark in Copenhagen tells us all about it. Guests: Dr. Lindsay Miles is an entomologist at Virginia Tech. Dr. Lars Vilhelmsen is a curator at the Natural History Museum of Denmark in Copenhagen Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Manu Prakash is many things—biologist, engineer, inventor, philosopher—but what he isn’t is conventional. Following his instincts has led Manu to his most ambitious project yet: mapping the whole tree of life, with the help of everyone on this planet. Step one: make a cheap microscope anyone can use. Foldscope co-inventor Jim Cybulski describes their invention, and their dream to supply millions of microscopes to the masses. Manu has been recognized by the Hypothesis Fund as a Scout for his bold science and enabling others to pursue their big ideas. “The Leap” is a 10-episode audio series that profiles scientists willing to take big risks to push the boundaries of discovery. It premieres on Science Friday’s podcast feed every Monday until July 21. “The Leap” is a production of the Hypothesis Fund, brought to you in partnership with Science Friday. Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

A mysterious disease called acute flaccid myelitis (AFM) has been appearing in emergency rooms for about a decade. The disease has caused otherwise healthy children to lose the ability to move their arms and legs, and some become completely paralyzed. AFM is caused by a virus that's a cousin of the polio virus, earning it the nickname "the new polio.” Journalist and physician Eli Cahan joins Host Flora Lichtman to explain what doctors have been observing, the research efforts toward developing a vaccine, and what this emerging disease reveals about our readiness for future outbreaks and pandemics. Read Cahan’s article about what fighting this “new polio” might look like as our healthcare infrastructure gets dismantled. And, learning more about some non-cancerous cells may help researchers better understand how cancer progresses. When you think about how cancer spreads in the body, you’re probably thinking about cancer cells—they divide uncontrollably, form into tumors, and hide from the immune system. So, it makes sense that studying the behavior of these cells is critical to our understanding of cancer. But now, researchers are looking more closely at the non-cancerous cells that co-exist within tumors and the surrounding tissues. They make up what’s called the “colocateome.” Taking this more holistic approach to cancer research may help explain why some treatments don't work for all patients, and eventually may lead to more effective therapies. To better understand this expanding field, Host Ira Flatow talks with Sylvia Plevritis, a Stanford University cancer researcher. Guests: Dr. Eli Cahan is a journalist and physician based in Boston, Massachusetts. Dr. Sylvia Plevritis is a professor of biomedical data science and radiology at Stanford University. Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

It’s a precarious time for science in the United States. Federal funding is being slashed, career scientists are being laid off, and researchers are considering leaving to work abroad. On top of that, public trust in science and experts has declined. Besides acknowledging the federal attacks on science, a lot of scientists are also asking themselves: What are we doing wrong? How do we engage the public? And what could we do better? Joining Host Flora Lichtman to dig through these questions is Felice Frankel, a science photographer and chemical engineer at MIT. She’s also the author of the upcoming book Phenomenal Moments: Revealing the Hidden Science Around Us, out this fall. Guest: Felice Frankel is a science photographer and a research scientist at the Massachusetts Institute of Technology in the department of chemical engineering. Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

South American cane toads were brought to Australia in 1935 to help eradicate native beetles that were destroying sugar cane crops. The toads didn’t care much for the beetles, but they did spread across the coast of Queensland and beyond, with no natural predators to stop them. Their own deadly toxin devastated local reptiles along the way, and they now number over 200 million. Invasive biologists have long tried to curb Australia’s cane toad population. The newest approach uses CRISPR gene-editing technology to create cannibalistic “Peter Pan” cane toad tadpoles: tadpoles that don’t fully mature and instead feast on the tens of thousands of eggs that the toads produce. How was this approach developed, and how do these researchers think about making a potentially massive change to the ecosystem? Biologist Rick Shine, who has led the effort, joins Host Flora Lichtman to discuss it. Later, science journalist Elizabeth Kolbert talks about her experience reporting on similar monumental efforts to control nature—and what they say about us. Guests: Elizabeth Kolbert is a staff writer at The New Yorker and author of Under a White Sky: The Nature of the Future (Crown, 2021). She’s based in Williamstown, Massachusetts. Dr. Rick Shine is a professor of biology at Macquarie University in Sydney, Australia. Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Birding is a hobby that attracts a very particular group of people: the kind who get up at sunrise, go into the woods, and wait for hours for a little tiny feathered friend to fly past. Author and illustrator Rosemary Mosco guides us into the world of birding with her new book, The Birding Dictionary. Plus, biologist Sara Lipshutz fills us in on the surprisingly high-drama world of some female birds. Guests: Rosemary Mosco is an author, illustrator, and speaker whose work connects people with the natural world. Her latest book is The Birding Dictionary. Dr. Sara Lipshutz is an assistant professor in biology at Duke University. Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

As a young plant scientist, Joanne Chory shook up the research establishment with her unconventional approach to figuring out how plants work. Her methods and success changed the field, and led her to her biggest project yet—tackling climate change, with the help of millions of plants. Colleagues Steve Kay, Detlef Weigel, and Jennifer Nemhauser describe what made Joanne outstanding in the field of plant scientists. Plus Joanne’s sister, Mary Ann Chory, describes their early family life and the sibling relationships that shaped them. Joanne Chory died in November 2024 at age 69 from complications due to Parkinson’s disease. “The Leap” is a 10-episode audio series that profiles scientists willing to take big risks to push the boundaries of discovery. It premieres on Science Friday’s podcast feed every Monday until July 21. “The Leap” is a production of the Hypothesis Fund, brought to you in partnership with Science Friday. Transcript is available on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

Grant funding by the National Science Foundation has been cut by more than half this year, bringing the foundation’s science funding to its lowest level in decades. Katrina Miller, who covers science for the New York Times, joins Host Flora Lichtman to unpack the cutbacks and discuss where the funding changes might lead. And, the FDA has cleared a blood test to help diagnose Alzheimer’s disease. The first-of-its-kind test measures the levels of amyloid and tau proteins in a patient’s blood, two major biomarkers of the disease. Alzheimer’s researcher Jason Karlawish joins Flora to explain this new diagnostic tool and what it means for patients. Guests: Katrina Miller is a science reporter for The New York Times based in Chicago. Dr. Jason Karlawish is a professor of medicine, medical ethics and health policy, and neurology at the University of Pennsylvania’s Perelman School of Medicine, and co-director of the Penn Memory Center, based in Philadelphia, Pennsylvania. Transcripts for each segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.

At the end of April, air traffic control radar surveillance and radio communication systems at Newark airport went dark for over a minute. A week and half later, radar went down again briefly. The Federal Aviation Administration (FAA) has since cut down the number of flights in and out of Newark. But, how does our air traffic control system work? How do air traffic controllers keep track of all of the planes in the sky? And what happens when systems fail? Michael McCormick, a former air traffic control operations manager at the FAA, joins Host Flora Lichtman to dive into the science of air traffic control. Guest: Dr. Michael McCormick is a former vice president of the FAA’s Air Traffic Organization, and an associate professor and program coordinator of Air Traffic Management at Embry-Riddle Aeronautical University. Transcripts for the segment will be available after the show airs on sciencefriday.com. Subscribe to this podcast. Plus, to stay updated on all things science, sign up for Science Friday's newsletters.